Preparation and Evaluation of IL-1ra-Loaded Dextran/PLGA Microspheres for Inhibiting Periodontal Inflammation In Vitro.
Identifieur interne : 000046 ( Main/Exploration ); précédent : 000045; suivant : 000047Preparation and Evaluation of IL-1ra-Loaded Dextran/PLGA Microspheres for Inhibiting Periodontal Inflammation In Vitro.
Auteurs : Jingyi Lu [République populaire de Chine] ; Baijie Ren [République populaire de Chine] ; Lei Wang [République populaire de Chine] ; Minghe Li [République populaire de Chine] ; Yue Liu [République populaire de Chine]Source :
- Inflammation [ 1573-2576 ] ; 2020.
Descripteurs français
- KwdFr :
- Adolescent (MeSH), Adulte (MeSH), Antagoniste du récepteur à l'interleukine-1 (composition chimique), Antagoniste du récepteur à l'interleukine-1 (pharmacologie), Anti-inflammatoires (composition chimique), Anti-inflammatoires (pharmacologie), Cinétique (MeSH), Copolymère d'acide poly(lactique-co-glycolique) (composition chimique), Dextrane (composition chimique), Enfant (MeSH), Fibroblastes (effets des médicaments et des substances chimiques), Fibroblastes (métabolisme), Gencive (effets des médicaments et des substances chimiques), Gencive (métabolisme), Humains (MeSH), Jeune adulte (MeSH), Libération de médicament (MeSH), Microsphères (MeSH), Médiateurs de l'inflammation (métabolisme), Parodontite (métabolisme), Parodontite (prévention et contrôle), Préparation de médicament (MeSH), Taille de particule (MeSH), Vecteurs de médicaments (MeSH).
- MESH :
- composition chimique : Antagoniste du récepteur à l'interleukine-1, Anti-inflammatoires, Copolymère d'acide poly(lactique-co-glycolique), Dextrane.
- effets des médicaments et des substances chimiques : Fibroblastes, Gencive.
- métabolisme : Fibroblastes, Gencive, Médiateurs de l'inflammation, Parodontite.
- pharmacologie : Antagoniste du récepteur à l'interleukine-1, Anti-inflammatoires.
- prévention et contrôle : Parodontite.
- Adolescent, Adulte, Cinétique, Enfant, Humains, Jeune adulte, Libération de médicament, Microsphères, Préparation de médicament, Taille de particule, Vecteurs de médicaments.
English descriptors
- KwdEn :
- Adolescent (MeSH), Adult (MeSH), Anti-Inflammatory Agents (chemistry), Anti-Inflammatory Agents (pharmacology), Child (MeSH), Dextrans (chemistry), Drug Carriers (MeSH), Drug Compounding (MeSH), Drug Liberation (MeSH), Fibroblasts (drug effects), Fibroblasts (metabolism), Gingiva (drug effects), Gingiva (metabolism), Humans (MeSH), Inflammation Mediators (metabolism), Interleukin 1 Receptor Antagonist Protein (chemistry), Interleukin 1 Receptor Antagonist Protein (pharmacology), Kinetics (MeSH), Microspheres (MeSH), Particle Size (MeSH), Periodontitis (metabolism), Periodontitis (prevention & control), Polylactic Acid-Polyglycolic Acid Copolymer (chemistry), Young Adult (MeSH).
- MESH :
- chemical , chemistry : Anti-Inflammatory Agents, Dextrans, Interleukin 1 Receptor Antagonist Protein, Polylactic Acid-Polyglycolic Acid Copolymer.
- chemical , metabolism : Inflammation Mediators.
- chemical , pharmacology : Anti-Inflammatory Agents, Interleukin 1 Receptor Antagonist Protein.
- drug effects : Fibroblasts, Gingiva.
- metabolism : Fibroblasts, Gingiva, Periodontitis.
- prevention & control : Periodontitis.
- Adolescent, Adult, Child, Drug Carriers, Drug Compounding, Drug Liberation, Humans, Kinetics, Microspheres, Particle Size, Young Adult.
Abstract
Periodontitis is a chronic infectious disease, the course and progression of which are determined by the interaction between microorganisms and the host. Interleukin 1β plays an important role in the destruction of periodontal tissues. Interleukin 1 receptor antagonist (IL-1ra) can inhibit the biological activity of IL-1β without triggering any intracellular signaling. This study aimed to prepare IL-1ra-loaded dextran/PLGA microspheres and evaluate the physical and chemical characteristics and anti-inflammatory properties. Results suggested that the microspheres can be easily prepared into a drug carrier with good biocompatibility and can effectively inhibit the gene expression of pro-inflammatory factors induced by IL-1β in human gingival fibroblasts. Hence, the microspheres are excellent candidate for periodontitis treatment.
DOI: 10.1007/s10753-019-01107-w
PubMed: 31664694
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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University, Changchun, 130021</wicri:regionArea><orgName type="university">Université de Jilin</orgName><placeName><settlement type="city">Changchun</settlement><region type="province">Jilin</region></placeName></affiliation></author><author><name sortKey="Ren, Baijie" sort="Ren, Baijie" uniqKey="Ren B" first="Baijie" last="Ren">Baijie Ren</name><affiliation wicri:level="4"><nlm:affiliation>Department of Periodontology, School and Hospital of Stomatology, Jilin University, Changchun, 130021, People's Republic of China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Periodontology, School and Hospital of Stomatology, Jilin University, Changchun, 130021</wicri:regionArea><orgName type="university">Université de Jilin</orgName><placeName><settlement type="city">Changchun</settlement><region type="province">Jilin</region></placeName></affiliation></author><author><name sortKey="Wang, Lei" sort="Wang, Lei" uniqKey="Wang L" first="Lei" last="Wang">Lei Wang</name><affiliation wicri:level="4"><nlm:affiliation>Department of Periodontology, School and Hospital of Stomatology, Jilin University, Changchun, 130021, People's Republic of China. wang_lei99@jlu.edu.cn.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Periodontology, School and Hospital of Stomatology, Jilin University, Changchun, 130021</wicri:regionArea><orgName type="university">Université de Jilin</orgName><placeName><settlement type="city">Changchun</settlement><region type="province">Jilin</region></placeName></affiliation></author><author><name sortKey="Li, Minghe" sort="Li, Minghe" uniqKey="Li M" first="Minghe" last="Li">Minghe Li</name><affiliation wicri:level="4"><nlm:affiliation>Department of Oral and Maxillofacial Surgery, Hospital of Stomatology, Jilin University, Changchun, 130021, People's Republic of China.</nlm:affiliation><country xml:lang="fr">République populaire de 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(pharmacology)</term><term>Kinetics (MeSH)</term><term>Microspheres (MeSH)</term><term>Particle Size (MeSH)</term><term>Periodontitis (metabolism)</term><term>Periodontitis (prevention & control)</term><term>Polylactic Acid-Polyglycolic Acid Copolymer (chemistry)</term><term>Young Adult (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent (MeSH)</term><term>Adulte (MeSH)</term><term>Antagoniste du récepteur à l'interleukine-1 (composition chimique)</term><term>Antagoniste du récepteur à l'interleukine-1 (pharmacologie)</term><term>Anti-inflammatoires (composition chimique)</term><term>Anti-inflammatoires (pharmacologie)</term><term>Cinétique (MeSH)</term><term>Copolymère d'acide poly(lactique-co-glycolique) (composition chimique)</term><term>Dextrane (composition chimique)</term><term>Enfant (MeSH)</term><term>Fibroblastes (effets des médicaments et des substances chimiques)</term><term>Fibroblastes (métabolisme)</term><term>Gencive (effets des médicaments et des substances chimiques)</term><term>Gencive (métabolisme)</term><term>Humains (MeSH)</term><term>Jeune adulte (MeSH)</term><term>Libération de médicament (MeSH)</term><term>Microsphères (MeSH)</term><term>Médiateurs de l'inflammation (métabolisme)</term><term>Parodontite (métabolisme)</term><term>Parodontite (prévention et contrôle)</term><term>Préparation de médicament (MeSH)</term><term>Taille de particule (MeSH)</term><term>Vecteurs de médicaments (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Anti-Inflammatory Agents</term><term>Dextrans</term><term>Interleukin 1 Receptor Antagonist Protein</term><term>Polylactic Acid-Polyglycolic Acid Copolymer</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Inflammation Mediators</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Anti-Inflammatory Agents</term><term>Interleukin 1 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xml:lang="en">Periodontitis is a chronic infectious disease, the course and progression of which are determined by the interaction between microorganisms and the host. Interleukin 1β plays an important role in the destruction of periodontal tissues. Interleukin 1 receptor antagonist (IL-1ra) can inhibit the biological activity of IL-1β without triggering any intracellular signaling. This study aimed to prepare IL-1ra-loaded dextran/PLGA microspheres and evaluate the physical and chemical characteristics and anti-inflammatory properties. Results suggested that the microspheres can be easily prepared into a drug carrier with good biocompatibility and can effectively inhibit the gene expression of pro-inflammatory factors induced by IL-1β in human gingival fibroblasts. Hence, the microspheres are excellent candidate for periodontitis treatment.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">31664694</PMID><DateCompleted><Year>2020</Year><Month>11</Month><Day>16</Day></DateCompleted><DateRevised><Year>2020</Year><Month>11</Month><Day>16</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1573-2576</ISSN><JournalIssue CitedMedium="Internet"><Volume>43</Volume><Issue>1</Issue><PubDate><Year>2020</Year><Month>Feb</Month></PubDate></JournalIssue><Title>Inflammation</Title><ISOAbbreviation>Inflammation</ISOAbbreviation></Journal><ArticleTitle>Preparation and Evaluation of IL-1ra-Loaded Dextran/PLGA Microspheres for Inhibiting Periodontal Inflammation In Vitro.</ArticleTitle><Pagination><MedlinePgn>168-178</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1007/s10753-019-01107-w</ELocationID><Abstract><AbstractText>Periodontitis is a chronic infectious disease, the course and progression of which are determined by the interaction between microorganisms and the host. Interleukin 1β plays an important role in the destruction of periodontal tissues. Interleukin 1 receptor antagonist (IL-1ra) can inhibit the biological activity of IL-1β without triggering any intracellular signaling. This study aimed to prepare IL-1ra-loaded dextran/PLGA microspheres and evaluate the physical and chemical characteristics and anti-inflammatory properties. Results suggested that the microspheres can be easily prepared into a drug carrier with good biocompatibility and can effectively inhibit the gene expression of pro-inflammatory factors induced by IL-1β in human gingival fibroblasts. Hence, the microspheres are excellent candidate for periodontitis treatment.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lu</LastName><ForeName>Jingyi</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Periodontology, School and Hospital of Stomatology, Jilin University, Changchun, 130021, People's Republic of China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ren</LastName><ForeName>Baijie</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Department of Periodontology, School and Hospital of Stomatology, Jilin University, Changchun, 130021, People's Republic of China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Lei</ForeName><Initials>L</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-0170-6422</Identifier><AffiliationInfo><Affiliation>Department of Periodontology, School and Hospital of Stomatology, Jilin University, Changchun, 130021, People's Republic of China. wang_lei99@jlu.edu.cn.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Minghe</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Oral and Maxillofacial Surgery, Hospital of Stomatology, Jilin University, Changchun, 130021, People's Republic of China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Yue</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Periodontology, School and Hospital of Stomatology, Jilin University, Changchun, 130021, People's Republic of China.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>20190303183SF</GrantID><Agency>the Jilin Province Science and Technology Research</Agency><Country></Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Inflammation</MedlineTA><NlmUniqueID>7600105</NlmUniqueID><ISSNLinking>0360-3997</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000893">Anti-Inflammatory Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D003911">Dextrans</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D004337">Drug Carriers</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D018836">Inflammation Mediators</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D053590">Interleukin 1 Receptor Antagonist Protein</NameOfSubstance></Chemical><Chemical><RegistryNumber>1SIA8062RS</RegistryNumber><NameOfSubstance UI="D000077182">Polylactic Acid-Polyglycolic Acid Copolymer</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000893" MajorTopicYN="N">Anti-Inflammatory Agents</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002648" MajorTopicYN="N">Child</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003911" MajorTopicYN="N">Dextrans</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004337" MajorTopicYN="Y">Drug Carriers</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004339" MajorTopicYN="N">Drug Compounding</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D065546" MajorTopicYN="N">Drug Liberation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005347" MajorTopicYN="N">Fibroblasts</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005881" MajorTopicYN="N">Gingiva</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018836" MajorTopicYN="N">Inflammation Mediators</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D053590" MajorTopicYN="N">Interleukin 1 Receptor Antagonist Protein</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007700" MajorTopicYN="N">Kinetics</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008863" MajorTopicYN="N">Microspheres</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010316" MajorTopicYN="N">Particle Size</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010518" MajorTopicYN="N">Periodontitis</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000517" MajorTopicYN="Y">prevention & control</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000077182" MajorTopicYN="N">Polylactic Acid-Polyglycolic Acid Copolymer</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Human gingival fibroblasts</Keyword><Keyword MajorTopicYN="N">Interleukin 1 receptor antagonist</Keyword><Keyword MajorTopicYN="N">Microsphere</Keyword><Keyword MajorTopicYN="N">Periodontitis</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2019</Year><Month>10</Month><Day>31</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>11</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2019</Year><Month>10</Month><Day>31</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">31664694</ArticleId><ArticleId IdType="doi">10.1007/s10753-019-01107-w</ArticleId><ArticleId IdType="pii">10.1007/s10753-019-01107-w</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>République populaire de Chine</li></country><region><li>Jilin</li></region><settlement><li>Changchun</li></settlement><orgName><li>Université de Jilin</li></orgName></list><tree><country name="République populaire de Chine"><region name="Jilin"><name sortKey="Lu, Jingyi" sort="Lu, Jingyi" uniqKey="Lu J" first="Jingyi" last="Lu">Jingyi Lu</name></region><name sortKey="Li, Minghe" sort="Li, Minghe" uniqKey="Li M" first="Minghe" last="Li">Minghe Li</name><name sortKey="Liu, Yue" sort="Liu, Yue" uniqKey="Liu Y" first="Yue" last="Liu">Yue Liu</name><name sortKey="Ren, Baijie" sort="Ren, Baijie" uniqKey="Ren B" first="Baijie" last="Ren">Baijie Ren</name><name sortKey="Wang, Lei" sort="Wang, Lei" uniqKey="Wang L" first="Lei" last="Wang">Lei Wang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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